Mr Cameron has been urged to spell out what powers he wants to claw back from Brussels and when negotiations on this might begin but he has appeared to rule out such a possibility in the short term and his Lib Dem coalition partners are wary of such a step.
But Tory MPs have said negotiations on amending EU treaties to allow for closer fiscal integration among eurozone members could start as early as next month and the UK must be prepared for this.
In his speech, the prime minister warned that Europe is "slipping behind" other economic powers and that unless it becomes more competitive, it will remain a "continent in trouble".
But he insisted that the UK's future remains within the EU, not outside it.
"Leaving the EU is not in our national interest," he will argue. "Outside, we would end up like Norway, subject to every rule for the single market made in Brussels but unable to shape those rules.
"Believe me, if we weren't in there helping write the rules they would be written without us - the biggest supporter of open markets and free trade - and we would not like the outcome."
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